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Furthermore, powerful evidence has emerged to show that GIPR signaling can enhance GLP-1-induced weight loss (73)

doi:10.1038/s44294-026-00128-9

ISSN 0016-6731

Another report showed that autophagic responses were significantly diminished in OLETF rats after experimental myocardial infarction associated with a deficiency in AMPK/ULK-1 activation, Akt/mTOR/S6 signaling, and increased Beclin-1-Bcl-2 interaction, which are key molecular events for suppressing autophagy