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Regular monitoring of complete blood counts (CBC) is essential, particularly in the first two cycles of therapy when nadirs are most unpredictable

Interactions with certain cardiovascular medications are possible, warranting close monitoring of therapeutic effects

The combination may produce better outcomes than either alone, though this has not yet been studied in controlled trials

In support of this increased NK cytotoxic potential, the expression of the NK cytotoxic effector-associated gene perforin, as determined by flow-cytometric analysis or quantitative real-time PCR analysis in CD56 + NK cells, was also significantly increased in the above IGF-1-induced CD34 + -derived NK cells compared with the cells without IGF-1 (Fig