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This dual mechanism is why tirzepatide consistently outperforms every other weight loss medication in head-to-head clinical evidence

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The most common adverse effects for both are gastrointestinal : Nausea the most frequently reported effect, usually worst when starting or increasing the dose Diarrhea and constipation Vomiting Decreased appetite and, occasionally, abdominal discomfort These effects are typically mild to moderate , dose-dependent, and tend to ease over time as the body adjusts