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Abbreviations Ach acetylcholine BALF broncho-alveolar lavage fluid CGRP calcitonin gene-related peptide COPD chronic obstructive pulmonary disease DOX doxycycline FDA Food and Drug Administration FEV 1 forced expiratory volume in the first second FVC forced vital capacity GSH glutathione HDAC histone deacetylase complex hPBMCs human peripheral blood mononuclear cells HRQoL health-related quality of life hs-CRP high-sensitivity C-reactive protein IFN interferon-gamma IL interleukin iNOS induced nitric oxide synthase IPF idiopathic pulmonary fibrosis LPS lipopolysaccharides MCHC mean corpuscular hemoglobin concentration MCP-1 monocyte chemotactic protein-1 MCV mean corpuscular volume MDA malondialdehyde MMEF maximum mid-expiratory flow MMPs matrix metalloproteinase NAC N-Acetylcysteine NFkB nuclear transcription factor NK cells natural killer cells OVA ovalbumin PaCO 2 arterial blood carbon dioxide PE pulmonary embolism PEF peak expiratory flow PFT pulmonary function tests ROS reactive oxygen species SaO 2 arterial blood oxygenation saturation SIL-BS silibinin-bis-succinat SM sulfur mustard TAT thrombin anti-thrombin TFPI tissue factor pathway inhibitor TGF-1 transforming growth factor beta1 TNF tumor necrosis factor- tPA tissue plasminogen activator TR tracheal responsiveness TSM tracheal smooth muscle WBC white blood cells

Moderate changes of the K m app values in combination with the altered k cat app values resulted in decreased apparent catalytic efficiencies of E170A/K for both substrates as compared with the wild-type enzyme and E170D (Fig

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Proteomic analysis of the Arabidopsis thaliana - Botrytis cinerea interaction using two-dimensional liquid chromatography