While fat is needed in the diet, it is best to opt for heart-healthy options such as fish, olive oil, nuts, seeds, and avocados (American Heart Association 2025)

FIGURE 1 3 IGF-1 and its signal transduction pathway IGF-1, organically named somatomedin C, is a multifunctional peptide mitogen possessing a molecular weight of 7,649 daltons ( Following either local secretion or systemic circulation to target tissues, IGF-1 primarily exerts its biological effects through binding to the IGF-1 receptor (IGF-1R), with minimal interaction occurring through the insulin receptor (IR) (Figure 2) ( FIGURE 2 In addition to IGF-1R, insulin-like growth factor binding proteins (IGFBPs) are also required for IGF-1 bioavailability because they interact with IGF-1 with the same affinity as IGF-1R ( 4 Tendon scar healing Following a tendon injury, the healing process unfolds through three overlapping phases: (1) the inflammatory phase, (2) the proliferative phase, and (3) the remodeling phase ( 5 The expression profile of IGF-1 in tendon healing A controlled delivery strategy for IGF-1, which accounts for the spatiotemporal complexity of the injury microenvironment and synergizes with endogenous IGF-1 production through feedback mechanisms, holds significant promise for enhancing IGF-1 therapy ( In the early-peaked studies, Hansson et al

When administered correctly, it can speed up recovery, relieve chronic joint pain, and reduce the need for invasive treatments or long-term medications
How to Increase Glutathione in Your Body Now that we understand the significance of glutathione and the factors affecting its levels, let's explore various strategies to naturally boost glutathione production