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Shima Hadidchi, MD recognizes that each patients response to Zepbound (tirzepatide) can be different

Retatrutide + MOTS-c Storage & Handling Storage Reference (Both Compounds) State Lyophilized (long-term) Retatrutide -4 F (-20 C), 12+ months MOTS-c -4 F (-20 C), 12+ months State Lyophilized (short-term) Retatrutide 35.6-46.4 F (2-8 C), several months MOTS-c 35.6-46.4 F (2-8 C), several months State Lyophilized (room temp) Retatrutide Weeks (shipping tolerance only) MOTS-c Weeks (shipping tolerance only) State Reconstituted (liquid) Retatrutide 35.6-46.4 F (2-8 C), up to 28-60 days MOTS-c 35.6-46.4 F (2-8 C), up to 7 days State Aliquot frozen reconstituted Retatrutide Not standard practice MOTS-c -4 F (-20 C), 2-3 months State Color when reconstituted Retatrutide Clear MOTS-c Clear State Light protection Retatrutide Yes MOTS-c Yes State Oral viable Retatrutide No MOTS-c No MOTS-c's 7-day reconstituted window is the limiting factor for storage planning

Cross-trial comparisons carry inherent limitations: baseline populations vary, treatment timelines differ (72 weeks vs

Both tirzepatide and semaglutide carry black box warnings about an increased risk of thyroid tumors , including a rare form of thyroid cancer (medullary thyroid carcinoma)