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Beyond pricing and utilization, Diede highlighted a broader set of uncertainties that actuaries must incorporate into long-term projections

Bone is constantly renewing itself

Both conditions feature elevated prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) via Cyclooxygenase-1 (COX-1)/Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) activation, respectively, which amplify neuroinflammation (microglial activation) and synovial inflammation (fibroblast activation) (200, 302)

"They were living 32 weeks in a condition that was more optimal for their body, in terms of some of these biomarkers of aging," Corley said