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As mentioned before, tirzepatide also works on GIP receptors

Importantly, gastrointestinal adverse events (nausea, vomiting, diarrhoea) occurred in 3045% of participants during dose escalation but typically resolved within 48 weeks

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oral semaglutide based on the PIONEER 2 study [55], the treatment policy estimand for HbA1c impacts was used in the base case, which includes the use of rescue medications (e.g., including insulin)