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Tirzepatides dual agonist mechanism may accelerate progress, with some people reporting accelerated weight drops during the second month especially at doses above 10 mg (Journal of Clinical Medicine Research)

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By improving insulin sensitivity, it accelerates fat burning, especially during calorie reduction or increased physical activity

In one analysis, individuals with obesity treated with GLP-1s incurred significantly higher annual healthcare costs than individuals with obesity without GLP-1 use ($7000 higher in the first year, and $4200 higher in the second year)