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However, dietary supplements, while recommended in some cases, cannot replace a healthful diet. The Dietary Guidelines for Americans describe a healthy diet as one that: Emphasizes a variety of fruits, vegetables, whole grains, and fat-free or low-fat milk and milk products: Milk and milk products are good sources of vitamin B12

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This article explores the scientific evidence, clarifies when B12 supplementation might be associated with anxiety-like symptoms, and provides guidance on safe management aligned with UK clinical practice and NICE recommendations

Last reviewed: June 15, 2026 Last updated: June 15, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations