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Journal of Clinical Oncology 41(3):460-471, 2023

Indeed, binding AGEs and AOPPs to the RAGE activates genes and transcription factors that produce pro-inflammatory cytokines (TNF-, IL-1), chemokines (CCL19, CCL-21, CXCL-8), metalloproteinases (collagenase-1 [MMP-1], gelatinase A [MMP-2]), adhesion molecules (very late antigen-1 [VLA1], CD49 antigen-like family member A/CD29 (1)-integrin [CD49a/CD29]), cyclooxygenases 2 (COX-2), and nitric oxide synthases (NOS) 76

However, if you have specific health concerns or conditions, we recommend consulting with your healthcare provider before starting IV therapy

Regularly, VEGF in the tumor microenvironment mobilizes VEGFR-2-positive EPCs from the bone marrow to initiate vasculogenesis (Lugano et al., 2020)