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Best nootropics and brain supplements at a glance The best nootropics and brain supplements may help support: Focus and concentration Memory and learning Mental clarity Cognitive performance Stress resilience Mood and motivation Brain aging support Top evidence-backed natural nootropics include: Lions mane mushroom Bacopa monnieri Ginkgo biloba Omega-3 fish oil Rhodiola rosea L-theanine Panax ginseng Creatine Ashwagandha Citicoline Some nootropics may help improve attention, memory retention and mental energy, but results vary depending on dosage, ingredient quality, sleep, diet and overall health