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GHRP-6 induces strong orexigenic effects via ghrelin receptor activation, while GHRP-2 produces a less pronounced appetite response. Nagaya , Circulation Water Retention and Bloating Both GHRP-6 and GHRP-2 can cause transient water retention , particularly during the first few weeks of use, due to elevated aldosterone and GH/IGF-1 levels: Users may notice mild bloating or a temporary increase in body weight from water retention