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These include: Lifestyle interventions (dietary advice, physical activity programmes) Licensed pharmacotherapy such as orlistat, or GLP-1 receptor agonists including semaglutide 2.4 mg (Wegovy, NICE TA875) or tirzepatide (Zepbound) where clinically indicated and available Referral to tier 3 or tier 4 weight management services , including bariatric surgery assessment where appropriate Information on NHS weight management services and eligibility for licensed treatments is available via the NHS website and NICE guidance

GHK-Cu is also a regular constituent in human plasma, existing at approximately 200 ng/ml at age 20 and dropping to 80 ng/ml at age 60

While their active presence diminishes within a few days, their benefits, such as reduced inflammation, may last longer

Res 14 , 13351342 (2019)