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Nathan DM, Davidson MB, DeFronzo RA, et al

Safety and tolerability were assessed using the safety analysis set (all patients exposed to 1 dose of trial product) and evaluated both on treatment while participants were receiving trial product regardless of rescue medication use and in trial while participants remained in the trial regardless of trial product discontinuation or rescue medication use

Therefore, both clinicians and patients should be aware of this trend [40]

While results from IV ALA studies are consistently positive, the picture is more mixed when it comes to oral-only supplementation: A four-year randomized trial found no significant improvement in a composite measure of nerve function with 600mg/day of oral ALA compared to placebo