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Negative controls containing vehicle (DMSO, maximum concentration of 0.5%) were included

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Results at 68 weeks: 40.4% of CagriSema participants lost 25% or more of their body weight 91.9% lost at least 5% Blood pressure fell by 10.9 mmHg systolic on average About 40% of participants reduced or stopped blood pressure medications 87.7% of those with prediabetes at baseline achieved normal blood sugar Results were published in the New England Journal of Medicine and presented at the American Diabetes Associations 2026 Scientific Sessions

These issues reflect Cochrane Librarys recommendation for need for independent evidence, both for the short-term and long-term use of GLP-1s