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doi: 10.1210/jc.2003-031403 193 OjimaAIshibashiYMatsuiTMaedaSNishinoYTakeuchiMet al

Furthermore, ROS-induced oxidative inactivation of PTP1B phosphatase at the Cys215 site exacerbates insulin signaling transduction impairment [344]

AKI can potentially elicit reactions comparable to those observed in CKD, including enhanced cytokine production, higher level of inflammatory cell infiltration, epithelial to mesenchymal transition, and activation of fibroblasts (Lv et al., 2018

In lab and clinical research, its been observed to activate fibroblasts (the cells that produce collagen), increase glycosaminoglycan synthesis (which helps skin retain water), modulate matrix metalloproteinases (MMPs, the enzymes that break down old tissue), and act as a copper cofactor in antioxidant pathways