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These include: Diuretics (furosemide, hydrochlorothiazide) which can exacerbate volume depletion ACE inhibitors or ARBs (lisinopril, losartan) which may cause acute kidney injury when combined with dehydration NSAIDs (ibuprofen, naproxen) which reduce kidney blood flow SGLT2 inhibitors (empagliflozin, dapagliflozin) which cause osmotic diuresis, though these medications have proven renal and cardiovascular benefits and should not be discontinued without medical advice Advanced age (over 65 years) and cardiovascular disease also increase vulnerability to kidney injury