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Notably, the high levels of heterogeneity in the studies analyzed as well as other measures such as variability in study populations, interventions and methodologies, could have affected the reliability of the results obtained

The most commonly reported include: Nausea Constipation or diarrhoea Heartburn or reflux Feeling overly full Reduced appetite that can lead to under-eating Practical pharmacist guidance that helps: Smaller meals, slower eating, prioritise protein and fibre Hydration targets and electrolytes when needed Dose timing strategies and symptom tracking Reviewing other medicines (some can worsen nausea or constipation) Seek urgent medical advice for severe or persistent symptoms, especially severe abdominal pain, vomiting that does not settle, or signs of dehydration

Appetite Suppression Without Suffering

doi:10.1073/pnas.1301816110 Mazza A, Cicero AF, Ramazzina E, et al