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On the other hand, gastric emptying is not considerably impacted by glucose-dependent insulinotropic polypeptide (GIP), emphasizing the distinct functions of these incretins in GI function ( A study examined the potential advantages and disadvantages of using GLP-1RAs to help obese but non-diabetic patients lose weight

The dual composite endpoint of HbA1c below 7% plus 10% or more weight loss was achieved by 48% of mazdutide patients versus 21% on semaglutide

Available online at: 10.2196/preprints.32487 70

This review aims to summarize the mechanistic and therapeutic evidence for GLP-1 RAs in targeting key aging processes and their potential to restore cellular homeostasis and enhance healthspan