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Notably, two irregular brown spots with smooth and flat surface were observed on the left first toenail (Figure 1d1f)

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In a case-control study involving 105 patients [43] , heterozygous MC4R pathogenic/likely pathogenic (P/LP) variant carriers exhibited similar maximum total body weight loss percentage (%TBWLmax) to non-carriers (28.3% 8.5% vs

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