foxo4-dri senolytic 2023 2024 study ES2 rapidly destroys TP53-FOXO4 foci leading to TP53 mediated Molecular modelling of the FOXO4-TP53

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Published studies demonstrate: Significant TERT upregulation in human somatic cells (WI-38, HEK, diploid fibroblasts) after Epitalon exposure Telomere length preservation in replicatively aged fibroblast cultures (Q-FISH, TRF Southern) Life-span extension in multiple model organisms (Drosophila melanogaster, Ceriodaphnia affinis) in controlled laboratory studies Association with reduced age-related chromosomal instability and aneuploidy in long-term culture models GHK-Cu does not directly activate telomerase and has not been documented to significantly alter telomere length

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