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Contraindications Do Not Use If You Have a known hypersensitivity to methionine, inositol, choline, B12, or any component of the formulation Have severe liver disease or hepatic encephalopathy (caution with methionine) Have severe kidney disease Have homocystinuria (inherited metabolic disorder affecting methionine metabolism) Are pregnant or breastfeeding (except under specific medical supervision) Warnings and Precautions Methionine: High doses can elevate homocysteine levels, which has been associated with cardiovascular risk Choline: Very high doses can cause a fishy body odor, sweating, and low blood pressure Inositol: Generally well-tolerated

Currently, there is no evidence suggesting that tirzepatide directly worsens AMD or that patients with AMD should avoid this medication