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Malaguarnera M, Bella R, Vacante M, Giordano M, Malaguarnera G, Gargante MP, et al

Specifically, lipid peroxidation products such as 4-HNE can act as endogenous danger signals, activating the NF-B pathway and the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, subsequently triggering the release of potent inflammatory cytokines like IL-1 and tumor necrosis factor-alpha (TNF-)

The actual patch works just fine after some small frustration

A Note About Thyroid Concerns While early animal studies showed a potential increased risk of thyroid cancer, this hasnt been replicated in human studies