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Figures 1B , 3 ), resulting in down-regulation of the hepatic GHR expression, as inferred from reductions in circulating levels of GHBP (59), and decreased GH binding (60)

For example, in a recent pilot study of patients with early-stage breast cancer who received neoadjuvant talazoparib, multiplex immunofluorescence staining was performed to examine the changes in tumor immune microenvironment