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Inhaled corticosteroids (for asthma), systemic prednisone, and immunosuppressants used in autoimmune disease or post-transplant care all significantly reduce local and systemic immune competence, allowing Candida to proliferate without adequate immune restraint

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In studies using human fetal fibroblast cultures, Epithalon treatment extended cellular proliferative potential from termination at the 34th passage in control populations to beyond the 44th passage in treated cells, effectively surpassing the Hayflick limitthe maximum number of divisions normal cells can undergo before senescence