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Conclusion and prospects The occurrence of ferroptosis can be summarized as disruption of iron metabolic homeostasis or System X c /GSH/GPX4 pathway by various factors causing the depletion of cellular antioxidants and amplification of ROS production, ultimately leading to the accumulation of lipid peroxides and triggering ferroptosis

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Additionally, Suhayda & Walton (2002) highlight the role of healthcare professionals in managing fluid and electrolyte imbalances, particularly in older adults

Other agents in development include mazdutide , cagrilintide , survodutide, and orforglipron (an oral small-molecule GLP-1 agonist)