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Specifically, data from tirzepatide discontinuation indicated a BMI rebound of 4.3 units between weeks 36 and 88, translating to 0.083 kg/m 2 /week, 33 which was extrapolated to estimate weight regain after treatment

This off-period can lead to breakthrough hunger, reduced appetite suppression, and weaker metabolic effects when you need them most

If forced to generalize, tirzepatide edges out semaglutide for total side effect burden, but the difference is modest

Healthcare providers may suggest patients switch from Ozempic to Zepbound or Wegovy for weight loss due to individual responses, availability, cost, or specific health goals