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Bmc Musculoskeletal Disorders , 14 , 209

It stimulates collagen production, supports the breakdown of damaged tissue, encourages the growth of new blood vessels, and has direct antioxidant and anti-inflammatory effects

Despite extensive in vitro (cell culture) and gene expression data, there are relatively few large-scale, randomized controlled trials on topical GHK-Cu for anti-aging in human skin

Put plainly, the off period is not there because the compound stops working it is there because no one can point to human data showing that running it indefinitely is safe, and a scheduled break is the honest way to respect that gap