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Notably, the absence of tumor suppressor genes located on chromosome 10, including PTEN, is detected in a considerable portion (30%60%) of non-inherited melanomas

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The delay in Hgf and Cyclin D1 expression also coincided with differences in the kinetics of ERK1/2 phosphorylation between the two mice genotypes, suggesting that growth factor stimulation required for hepatocyte progression up to G1/S boundary was also altered

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For example, piracetam was able to reduce the accumulation of lipofuscin in rat brains

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