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The Role of Gut Microbiota in Obesity and Type 2 and Type 1 Diabetes Mellitus: New Insights into Old Diseases

Key considerations include: Pre-existing mental health conditions may be exacerbated during weight loss Physiological changes accompanying weight loss may affect emotional stability Medication effects on gastric emptying may reduce absorption of oral medications, including oral contraceptives (requiring backup contraception after initiation and dose increases) Social and lifestyle changes during treatment create psychological stressors Clinicians should maintain awareness that mood changes during Zepbound therapy likely represent multifactorial phenomena rather than simple cause-and-effect relationships

Menopause, central body fatness, and insulin resistance: effects of hormone-replacement therapy