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For physicians, it is important to understand the comparative profiles of these agents differences in dosing, efficacy, and safety to individualize therapy

In a clinical trial of more than 3,000 adults with obesity, participants who received the highest dose of orforglipron, 36 milligrams, lost 11.2% of their body weight -- about 25 pounds on average -- over more than 16 months

Because the drugs act on powerful metabolic levers, they've also since proven useful against obesity, heart disease, sleep apnea, as well as potentially addiction and now cancer

These include compounded versions of GLP-1 medications such as Semaglutide Compound