This metabolic shift increases relative dehydration riska critical concern because creatine supplementation draws intracellular water, further stressing hydration status
Toxicol Sci 112:521531 Antoine DJ, Jenkins RE, Dear JW, Williams DP, McGill MR, Sharpe MR, Craig DG, Simpson KJ, Jaeschke H, Park BK (2012) Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity
Future studies should investigate total microbial mass and metabolic pathways using biochemical analysis, proteomics, transcriptomics and genomics 40,45 and include a control group grown in anaerobiosis with these 3 antioxidant molecules
101 Topical applications of HA have been widely used to manage recurrent aphthous ulcers in the oral mucosa 103,104 providing rapid symptom relief