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1,2 While the primary endpoint in the majority of clinical trials was mean change in A1C, mean change in body weight was generally evaluated as a confirmatory secondary endpoint

Additionally, the mechanical stress experienced by the TMJ and the knee differs, with the TMJ being subjected to complex movements and loads during jaw function, while the knee experiences primarily compressive and shear forces

This interaction might lead to changes in how the body regulates temperature, possibly causing hot flashes or other temperature-related side effects

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