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Canagliflozin for primary and secondary prevention of cardiovascular events: results from the CANVAS program (Canagliflozin cardiovascular assessment study)

[DOI] [PubMed] [Google Scholar] 212.Simonen M, Dali-Youcef N, Kaminska D, Venesmaa S, Kkel P, Pkknen M, Hallikainen M, Kolehmainen M, Uusitupa M, Moilanen L, Laakso M, Gylling H, Patti ME, Auwerx J, Pihlajamki J

Efficacy and safety of GLP-1 receptor agonists versus SGLT-2 inhibitors in overweight/obese patients with or without diabetes mellitus: a systematic review and network meta-analysis

The net effect is increased production plus slower removal, a twofold push toward symptoms