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Figure 5 While compelling evidence establishes ferroptosis as a selective vulnerability of RCC and validates its potential for therapeutic exploitationvia natural compounds, reversal of drug resistance, and combination regimensseveral critical, insufficiently addressed research gaps persist

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There are currently no effective treatments for ALS and therapy is limited to symptomatic and palliative treatment (Miller et al., 2012) and edaravone (Rothstein, 2017) are the only approved pharmacological therapies that increase the survival rate by 23 months (Dorst et al., 2017

However, GSH levels did increase in a subset of participants with low GSH and high MDA levels at baseline 19