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LNP preparation All lipids used in this study were purchased from commercial vendors: DLin-MC3-DMA from Cayman Chemicals, Cholesterol from Sigma-Aldrich and DSPC and PEG2000-DMG from Avanti Polar Lipids

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The study showed that the renal extraction of GLP-1, natriuretic effect of GLP-1 and change of plasma concentrations of ANG II was abolished by the GLP-1 receptor antagonist Exendin 939 (Ex 939), suggesting that GLP-1-induced natriuresis is dependent on GLP-1 receptor activation 38

The latest TEXAIS results in 2023 were negative with a certain trend, which might be limited by the small sample size, short treatment duration and lack of medium to long-term therapeutic evaluation