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GLP-RT differs from earlier incretin peptides because it activates three metabolic hormone receptors: GLP-1R, GIPR, and GCGR, all within a single molecular structure

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[2] The reasoning behind the local designation was structural as much as functional: because the E-domain reading-frame shift alters the C-terminal sequence, the variant was predicted to interact differently with the binding proteins present in muscle interstitial spaces, keeping its action localized and its half-life short