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Hypoglycaemia (low blood sugar levels) GLP-1 RAs are glucose-dependent stimulators of insulin, meaning they shouldnt cause dangerous hypoglycemia on their own in a healthy person (unlike taking insulin)

The mechanism involves GLP-1 receptors in the ventral tegmental area and nucleus accumbens, the brain regions responsible for reward and pleasure

Journal reference: Chen, Bandy, et al

As initially explained in the September 8, 1998, OPPS/ASC proposed rule (63 FR 47576), we believe that using the IPPS wage index as the source of an adjustment factor for the OPPS is reasonable and logical, given the inseparable, subordinate status of the HOPD within the hospital overall