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Description

Pasireotide (SOM230) demonstrates efficacy and safety in patients with acromegaly: a randomized, multicenter, phase II trial

The canonical model of class B GPCR activation, known as the "two-domain" model, describes a sequential binding process

Some of the enzymes involved are allosterically stimulated by intermediates of the pathway (e.g., stimulation of pyruvate kinase by fructose diphosphate)