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About 1 out of 3 people with lupus produce an antibody that attacks certain blood-clotting factors, which can cause the blood to clot easily

Another major driving hypothesis states that these conditions, by increasing reactive oxygen species (ROS) and nitrogen species (RONS), are capable of altering the balance of the redox status of both the steroidogenic cell population and the germ line cell populations, causing the disruption of the hypothalamicpituitarytesticular axis and the impairment of sperm quality [22]

93,94,95,96 Dysfunctional lysosomes and genetic variants such as IRGM further exacerbate disease progression

4a, b), which was not affected by the inclusion of TNF in the media (Fig