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When it declines in menopause, women lose many of these protective effects: Improves Insulin Sensitivity enhances how liver, muscle, fat, and pancreatic cells respond to insulin, keeping blood sugar balanced. Supports Pancreatic Function protects insulin-producing beta cells, helping prevent impaired glucose control. Reduces Inflammation lowers pro-inflammatory markers that drive insulin resistance and weight gain. Optimizes Fat Distribution helps prevent visceral (abdominal) fat accumulation, instead favoring subcutaneous fat patterns that are less harmful. Regulates Appetite and Energy signals brain centers that influence hunger and energy expenditure. Protects Cardiovascular Health improves cholesterol, vascular function, and metabolism, lowering cardiometabolic risk. Without estrogen, menopause often leads to increased belly fat, higher blood sugar, and greater cardiovascular risk

Tirzepatide , the world's first dual GLP-1R/GIPR agonist, developed by Eli Lilly, has demonstrated superior weight loss effects compared to semaglutide

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