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Actualmente, est en curso el estudio Targeting Aging with Metformin (TAME), un amplio ensayo clnico aleatorizado y multicntrico para determinar los efectos de la metformina en el envejecimiento humano59

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Gaballa et al., Examples of redox-regulated pathways Many cellular functions have been already associated with redox regulation

Both lipoic acid and dihydrolipoic acid have been found to inhibit copper- and iron-mediated oxidative damage in the test tube (22, 23) and to inhibit excess iron and copper accumulation in animal models (24, 25)