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This effect can result in postural dizziness, orthostatic hypotension, falls, and dehydration, particularly in elderly individuals, patients with kidney disease, patients on either diuretics or medications that interfere with the renin-angiotensin-aldosterone system (e.g., angiotensin-converting-enzyme inhibitors, angiotensin receptor blockers), and patients with low systolic blood pressure (138) (package insert)

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Hypocalcemia, most often resulting from hypoparathyroidism or vitamin D deficiency, significantly impairs cardiac function by disrupting calcium-dependent myocardial contraction and rhythm regulation (99, 100)