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Furthermore, as trauma is undoubtedly at the origin of PD and even micro-injuries may bear serious consequences in genetically predisposed patients, even injections must be considered a source of microtrauma for the tissues, therefore we made sure to use a very thin needle when performing the injections in the area around the plaque, and we decreased the number of injections at every treatment cycle

Since this review is about peptide ligands, the focus is on peptide- and protein-based pharmaceuticals, and the many examples of small molecules that bind to albumin are not discussed