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Description

Response: We believe not adopting this definition at this time provides the agency the opportunity to monitor and assess how such a definition may affect ASP, especially as we intend to finalize mandatory submission of reasonable assumptions

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Additional quality assessments evaluate physicochemical characteristics relevant to laboratory use, including solubility, molecular integrity, and stability under recommended storage conditions

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The influence of substituents on acidity is more pronounced in DMSO than in water, so Hammett parameters derived from aqueous p K a values actually underestimate substituent effects in reactions performed in non-hydrogen bonding media

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