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Response: We believe not adopting this definition at this time provides the agency the opportunity to monitor and assess how such a definition may affect ASP, especially as we intend to finalize mandatory submission of reasonable assumptions
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Additional quality assessments evaluate physicochemical characteristics relevant to laboratory use, including solubility, molecular integrity, and stability under recommended storage conditions
The influence of substituents on acidity is more pronounced in DMSO than in water, so Hammett parameters derived from aqueous p K a values actually underestimate substituent effects in reactions performed in non-hydrogen bonding media
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