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Were talking levels like 1200, 1500, 2000, or even 7500 pg/mL

It was found that a partial reduction of proteasomal activity results in an over-proliferation phenotype in sensitized backgrounds, suggesting that a proliferation promoting protein, or proteins, were not being properly degraded when proteasome activity was reduced

201 The STARS-ADHD clinical trial, which examined the efficacy of EndeavorRx on reducing ADHD symptoms, enrolled 857 patients aged 812 with ADHD and found that digital intervention significantly improved attention compared with a placebo intervention

The timeline appears to correspond with reaching therapeutic doses and allowing neurochemical adaptations to occur