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The increase in Ca 2+ is mediated by IP3 induced release of intracellular Ca 2+ and by depolarization leading to activation of voltage dependent Ca 2+ channels

Medical Pharmacology Chapter 2 General Principles: Pharmacokinetics Transition from first-order to zero-order kinetics is described by the Michaelis-Menten model of enzyme kinetics, which provides a mathematical description for saturable, capacity-limited elimination processes