bupropion and tirzepatide Zepbound (tirzepatide) induced anhedonia (the blahs or mehs) : r/Zepbound 📢 ACP Obesity Guidelines 2026

The report, which surveyed more than 2,300 UK adults, also found that many of these behaviours persist beyond treatment, with more than 80% of those who had stopped saying they had maintained at least some of the dietary and grocery changes adopted while taking GLP-1s

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K., Akhtar, M

This does not indicate a known risk, but rather highlights the need for ongoing research and careful monitoring over time