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The continuous disruption leads to kelpids and hypertrophic scars which can be viewed as an exuberant wound healing response, explained by a primary barrier abnormality [189]

Hyperpigmentation While melanotic macules are one result of hyperpigmentation, there are a few other avenues through which this excess melanin can cause dark spots on the lips

For example, through LC-MS/MS technology, researchers are able to quantify amino acids and acylcarnitines in plasma, which are considered potential biomarkers of metabolic syndrome

Another formulation, oral semaglutide (Rybelsus) , is a daily pill taken on an empty stomach